Fig. 6

Minocycline i.t. treatment inhibits L. amazonensis-induced hyperalgesia, but not paw edema. Mechanical (a) and thermal (b) hyperalgesia and paw edema (c) were measured in control non-infected and infected mice on day 30 after the infection, and subsequently, infected mice received i.t. injection of minocycline (microglia inhibitor, 50–150 μg) or vehicle for measurement of mechanical and thermal hyperalgesia and paw edema. Results are presented as mean ± SEM of six mice per group per experiment and are representative of two separate experiments. *p < 0.05 compared to control non-infected mice; ^#p < 0.05 compared to vehicle-treated infected mice; **p < 0.05 compared to 50 μg minocycline and vehicle-treated infected mice (one-way ANOVA followed by Tukey post hoc)