Fig. 7

α-Aminoadipate, minocycline, and PDTC i.t. treatments inhibit L. amazonensis-induced spinal cord GFAP, Iba-1, TNF-α, IL-1β, CX₃CR1, and CX₃CL1 increased mRNA expression. On day 30 after the infection, spinal cord GFAP (a), Iba-1 (b), TNF-α (c), IL-1β (d), CX₃CR1 (e), and CX₃CL1 (f) mRNA expression were determined in control non-infected and infected mice 7 h after treatments with vehicle, α-aminoadipate, minocycline, or PDTC by RT-qPCR. Results are presented as mean ± SEM of six mice per group per experiment and are representative of two separate experiments. *p < 0.05 compared to control non-infected mice; ^#p < 0.05 compared to vehicle-treated infected mice (one-way ANOVA followed by Tukey post hoc)