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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Meningitic Escherichia coli-induced upregulation of PDGF-B and ICAM-1 aggravates blood-brain barrier disruption and neuroinflammatory response

Fig. 7

Schematic presentation of meningitic E. coli induction of PDGF-BB and ICAM-1 for BBB disruption as well as neuroinflammatory responses. Infection-induced PDGF-BB mediates the decrease of TJ proteins to enhance permeability, and infection-induced ICAM-1 expression in endothelial cells largely promotes circulating monocytes or neutrophils to traverse the BBB and magnify neuroinflammatory responses

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Journal of Neuroinflammation

ISSN: 1742-2094