Fig. 4
From: Differential neuro-immune patterns in two clinically relevant murine models of multiple sclerosis
B cell localization in TMEV-IDD and R-EAE spinal cords. TMEV-IDD (day 120 post-infection) or R-EAE (day 14 post-immunization) decalcified spinal cords were stained with either a DAPI (blue), CD3 (green), and B220 (red) or b DAPI (blue), CD3 (green), and IgG (red) as indicated. Representative z stack projected compilations reveal immune cell aggregation in the ventral midline and ventral lateral meninges in TMEV-IDD and R-EAE mice, with minimal IgG immunostaining in R-EAE spinal cords. Insets in images show white boxed areas at higher magnification. Images are representative of 6 to 8 mice per group. Scale bar = 50 μm