Fig. 5

shLXRβ but not shLXRα abolished GW-mediated inhibition of phosphorylated MAPKs. Western blot analysis revealed shLXRα did not affect GW-mediated inhibition of elevated p-ERK (a, b) and p-JNK (c, d) in ACC induced by CFA and had no impact on p-p38 expression (e, f). However, shLXRβ abolished GW-mediated inhibition of p-ERK (g, h) and p-JNK (i, j) but did not affect p-p38 expression in CIP mice (k, l). Error bars represent SEM. n = 4, ^*p < 0.05, **p < 0.01 vs. Sham or shNC + Sham group; ^#p < 0.05 vs. shNC + CFA group; ^&p < 0.05, ^&&p < 0.01 vs. shLXRβ + Sham; ^@p < 0.05, ^@@p < 0.01 vs. shLXRα + CFA; ^$p < 0.05, ^$$p < 0.01 vs. shNC + CFA + GW