Fig. 1

BET inhibitor JQ1 reduces expression of pro-inflammatory and increases expression of anti-inflammatory cytokines and chemokines acutely after SCI. Real-time PCR quantification of a pro-inflammatory cytokines and chemokines at 4 and 72 h after SCI and b anti-inflammatory cytokines at 4 and 72 h after injury, normalized to the GAPDH levels. N = 4–5 mice per group and time. *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001 by one-way ANOVA followed by Tukey post hoc test. Data are represented as mean ± SEM fold changes of gene expression