Fig. 2

Microglia and infiltrating macrophages in the CNS have distinct gene profiles during neuroinflammation. Volcano plots of differential gene expression profiles showing the magnitude on the x-axis (Log2 fold change) and significance on the y-axis (-Log10 adjusted p value) for a infiltrating macrophages relative to homeostatic microglia, b infiltrating macrophages relative to reactive microglia, and c reactive microglia relative to homeostatic microglia. Upright arrows indicate set of genes upregulated in microglia or macrophages. Adjusted p value < 0.05 and a Log2 fold change > 2 are considered statistically significant. REACTOME pathway analysis for genes upregulated in infiltrating macrophages (d) and reactive microglia (e), was conducted using GSEA preranked tool