Fig. 5

Quantification of BrdU⁺ cells in the NeuN⁺ region of the hippocampal dentate gyrus. BrdU-positive neurons (green) are clearly visible in the granular zone of the dentate gyrus (a, b). Adjuvant metformin treatment did not promote neurogenesis neither after experimental PM nor in mock-infected animals, as no significant differences in BrdU⁺ cell counts was detected between animals receiving metformin treatment and animals receiving CRO monotherapy (c)