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Table 2 HLA association analysis of multiple sclerosis in the Japanese population

From: Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese

Variant

Frequency

Nominal analysis

HLA gene

MS (n = 45)

Control (n = 429)

OR (95% CI)

P

Fisher

HLA-B*15:01

0.200

0.078

2.95 (1.66–5.24)

2.2 × 10−4

 

HLA-B*39:01

0.122

0.043

3.09 (1.52–6.29)

0.0019

 

HLA-B*52:01

0.044

0.127

0.32 (0.08–0.88)

0.017

*

HLA-C*07:02

0.233

0.145

1.80 (1.07–3.04)

0.028

 

HLA-C*12:02

0.044

0.127

0.32 (0.08–0.88)

0.017

*

HLA-DMB*01:07

0.044

0.008

5.64 (1.19–22.7)

0.015

*

HLA-DOA*01:01

0.978

0.997

0.15 (0.03–0.94)

0.042

 

HLA-DPB1*05:01

0.522

0.356

1.98 (1.28–3.07)

0.0021

 

HLA-DQA1*01:02

0.267

0.156

1.96 (1.19–3.25)

0.0084

 

HLA-DQA1*03:03

0.222

0.141

1.74 (1.02–2.96)

0.042

 

HLA-DQB1*03:01

0.033

0.104

0.30 (0.06–0.93)

0.037

*

HLA-DQB1*04:01

0.222

0.100

2.56 (1.49–4.42)

7.0 × 10−4

 

HLA-DQB1*06:02

0.200

0.068

3.45 (1.93–6.17)

3.0 × 10−5

 

HLA-DRA*01:01

0.733

0.579

2.00 (1.23–3.25)

0.0053

 

HLA-DRA*01:02

0.267

0.421

0.50 (0.31–0.81)

0.0053

 

HLA-DRB1*04:05

0.233

0.120

2.23 (1.31–3.79)

0.0030

 

HLA-DRB1*15:01

0.211

0.072

3.44 (1.95–6.07)

2.1 × 10−5

 

HLA-DRB1*15:02

0.033

0.120

0.25 (0.05–0.79)

0.012

*

  1. *Fisher’s exact test was used for association analysis, otherwise logistic regression was used
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Journal of Neuroinflammation

ISSN: 1742-2094