Fig. 13

The effects of LCN2 on infarct volumes and functional outcomes after MCAO. a After mice being subjected to MCAO surgery, a magnetic resonance imaging (MRI) was performed. b, c On MRI T2 and DWI sequences, the LCN2-knockout mice had relative smaller infarct areas after MCAO than wild-type mice. The LCN2 overexpressed mice had larger infarct areas than negative controls. d, e The statistical results of MRI. f The mice were evaluated by modified Neurological Severity Score (mNSS). The LCN2 knockout mice had lower mNSS scores than WT mice (5.67 ± 0.33 and 11.00 ± 1.08, P < 0.01), and the LCN2 overexpressed mice tend to have higher mNSS scores than the controls (13.33 ± 0.67 and 10.67 ± 0.88, P = 0.07)