Fig. 4
Proposed mechanism of how PLG mediates the systemic inflammatory and neuroinflammatory response during an LPS challenge. (1) LPS injected IP gets into the bloodstream of mice. (2) Inflammatory signals in the blood lead to PLG cleavage into plasmin. (3) Plasmin, which mediates macrophage migration, acts on PLG-RKT receptors on PVMs. (4) PVMs release IL-1β and other cytokines and inflammatory mediators into the parenchyma of the brain which (5) causes activation of microglial cells