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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway

Fig. 4

DAPT and Notch1-RNAi alleviated MCAO/R and OGD/R injury in vivo and in vitro, respectively. a, b Brain infarct volume presented as a percentage of the intact hemisphere. *P < 0.05 vs. the MCAO/R group. c Neurological scores are presented as the median (interquartile range), *P < 0.05 vs. the MCAO/R group. d, e Neuronal apoptosis assayed by TUNEL, NeuN, and DAPI immunofluorescence staining. The percent of TUNEL and NeuN double-positive cells. **P < 0.01 vs. the MCAO/R group. f Notch1-RNAi significantly improved hippocampal neuronal proliferation rates on day 3 and day 7 after OGD/R injury. **P < 0.01 vs. the OGD/R group

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