Table 6 Comparison of the percentages of B cell subsets in IFN-β-treated MS patients stratified to the NEDA or EDA groups

Naïve (CD27⁻IgD⁺)

57.9 (46.6–64.6)

47.3 (29.4–54.8)

51.8 (41.4–60.6)

NS

–

–

–

Memory (CD27⁺)

12.2 (8.75–18.3)

8.87 (6.42–14.0)

22.7 (16.9–29.9)

< 0.001

0.009

< 0.001

NS

 CS⁺ Memory (CD27⁺IgD⁻)

10.8 (6.28–16.5)

7.74 (5.96–13.2)

18.8 (14.4–25.2)

< 0.001

0.017

< 0.001

NS

 CS⁻ Memory (CD27⁺IgD⁺)

1.66 (0.96–3.09)

0.96 (0.70–1.25)

3.49 (2.49–4.67)

< 0.001

NS (0.076)

0.002

NS

Plasmablasts (CD38^highCD20⁻)

0.37 (0.28–0.55)

0.32 (0.22–0.58)

0.37 (0.24–0.67)

NS

–

–

–

Transitional (CD24^highCD38^high)

6.73 (2.75–14.9)

4.56 (1.32–7.02)

3.14 (2.32–4.45)

NS

–

–

–