Skip to main content
Fig. 11 | Journal of Neuroinflammation

Fig. 11

From: Effect of Enterococcus faecalis 2001 on colitis and depressive-like behavior in dextran sulfate sodium-treated mice: involvement of the brain–gut axis

Fig. 11

Schematic representation of the anti-inflammatory and antidepressant effects of Enterococcus faecalis 2001 (EF-2001). The inflammatory cytokines derived from peripheral inflammation induced by treatment with dextran sulfate sodium may induce depressive-like symptoms via reduction of neurogenesis in the hippocampus (red arrow). The inhibition of inflammatory cytokines in the rectum may explain the anti-inflammatory and antidepressant effects of EF-2001 (blue arrow). Moreover, the antidepressant effect may be caused by neuroprotection via the modulation of XIAP in the hippocampus (blue arrow)

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094