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Table 3 Capacity of selected miRNAs to detect inflammatory activity in CNS

From: Analysis of miRNA signatures in CSF identifies upregulation of miR-21 and miR-146a/b in patients with multiple sclerosis and active lesions

 

AUC

95% CI

Sensitivity (%)

Specificity (%)

LR+

LR−

miR-21

0.703

0.543–0.863

60.00

77.78

2.70

0.51

miR-146a

0.728

0.553–0.904

90.48

64.71

2.56

0.15

miR-146b

0.712

0.531–0.894

81.82

66.67

2.45

0.27

miR-21 + miR-146a + miR-146b

0.867

0.736–0.997

94.12

69.23

3.06

0.08

  1. AUC area under curve, CI confidence interval, LR+ positive likelihood ratio, LR− negative likelihood ratio
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Journal of Neuroinflammation

ISSN: 1742-2094