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Table 3 Capacity of selected miRNAs to detect inflammatory activity in CNS

From: Analysis of miRNA signatures in CSF identifies upregulation of miR-21 and miR-146a/b in patients with multiple sclerosis and active lesions

 AUC95% CISensitivity (%)Specificity (%)LR+LR−
miR-210.7030.543–0.86360.0077.782.700.51
miR-146a0.7280.553–0.90490.4864.712.560.15
miR-146b0.7120.531–0.89481.8266.672.450.27
miR-21 + miR-146a + miR-146b0.8670.736–0.99794.1269.233.060.08
  1. AUC area under curve, CI confidence interval, LR+ positive likelihood ratio, LR− negative likelihood ratio