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Table 3 Capacity of selected miRNAs to detect inflammatory activity in CNS

From: Analysis of miRNA signatures in CSF identifies upregulation of miR-21 and miR-146a/b in patients with multiple sclerosis and active lesions

  AUC 95% CI Sensitivity (%) Specificity (%) LR+ LR−
miR-21 0.703 0.543–0.863 60.00 77.78 2.70 0.51
miR-146a 0.728 0.553–0.904 90.48 64.71 2.56 0.15
miR-146b 0.712 0.531–0.894 81.82 66.67 2.45 0.27
miR-21 + miR-146a + miR-146b 0.867 0.736–0.997 94.12 69.23 3.06 0.08
  1. AUC area under curve, CI confidence interval, LR+ positive likelihood ratio, LR− negative likelihood ratio