Table 2 Preclinical evidences supporting or opposing clinical application of COX-2 inhibitors for epilepsy treatment

Selective

Celecoxib

Electrical stimulation

[131]

[87]

Flurothyl

[96]

–

Kainic acid

[132]

[133, 134]

Pentylenetetrazol

[84]

–

Pilocarpine

[126, 135]

–

Etoricoxib

Genetic model

[136]

–

Pentylenetetrazol

[137]

–

Nimesulide

Bicuculline

[138]

–

Electrical stimulation

[6, 23]

–

Kainic acid

–

[134, 139]

Pentylenetetrazol

[140, 141]

–

Picrotoxin

[138]

–

NS-398

Kainic acid

[83]

[133]

Pilocarpine

[127, 142]

–

Parecoxib

Pilocarpine

[143]

–

Rofecoxib

Kainic acid

[144]

–

Pentylenetetrazol

[56, 140, 145]

[146]

SC-58125

Kainic acid

[82]

–

SC-58236

Electrical stimulation

–

[98, 147]

Pilocarpine

[127]

–

Non-selective

Aspirin

Electrical stimulation

[148]

–

Kainic acid

–

[133]

Pilocarpine

[149, 150]

[151]

Ibuprofen

Electrical stimulation

[148]

–

Indomethacin

Electrical stimulation

[148]

–

Kainic acid

–

[133, 151]

Others (metamizole, paracetamol, piroxicam, ketoprofen)

Electrical stimulation

[148]

–

Kainic acid

–

[134]