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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Astrocytic endothelin-1 overexpression promotes neural progenitor cells proliferation and differentiation into astrocytes via the Jak2/Stat3 pathway after stroke

Fig. 5

Stat 3 phosphorylation after tMCAO. a Representative immunoblot results at 7 days after tMCAO. b Semi-quantitative analysis of p-Stat3 protein demonstrating that p-Stat3 expression was upregulated after tMCAO both in Ntg and GET-1 mice. p-Stat3 expression was robustly upregulated in the ipsilateral in GET-1 mice brain tissue than in Ntg mice 7 days after tMCAO. N = 3 per group pooled together and assayed thrice. *p < 0.05, ***p < 0.001; Contra = contralateral side of the ischemic brain; Ips = ipslateral side of the ischemic brain. c Representative images of p-Stat3 expression in ipsilateral SVZ of each group (red, indicated by white arrows). Scale bar = 100 μm; LV = lateral ventricle, SVZ = subventricular zone

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Journal of Neuroinflammation

ISSN: 1742-2094