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Table 4 AG490 treatment reduces neurologic deficits in GET-1 and Ntg mice at 7 days after tMCAO

From: Astrocytic endothelin-1 overexpression promotes neural progenitor cells proliferation and differentiation into astrocytes via the Jak2/Stat3 pathway after stroke

Group

Neurological scores

Average scores

0

1

2

3

Ntg + vehicle(n = 15)

9

6

0

0

0.4

Ntg + AG490 (n = 8)

7

1

0

0

0.125

GET-1 + vehicle (n = 17)

1

9

7

0

1.35***

GET-1 + AG490 (n = 9)

4

3

2

0

0.78#

  1. Numbers of mice having various degrees of neurologic deficits after tMCAO. Numbers 0–3 in the top row represent severity of neurologic deficits with 0 being normal and 3 being the most severe
  2. Ntg nontransgenic, MCAO middle cerebral artery occlusion
  3. The asterisk denotes significant difference between the mean neurological scores of Ntg and GET-1 mice, p < 0.01
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Journal of Neuroinflammation

ISSN: 1742-2094