Fig. 1

EAE primarily affects female DRGs over males at the transcriptional level. a Joined volcano plots of DEGs; female DEGs = 3520, male DEGs = 189. Vertical dotted lines represent log₁₀(q = 0.1) as a cutoff threshold for significance. b Principal component analysis suggests separation of the EAE and CFA DRGs when analyzed by all mRNA sequencing data. Top two components are plotted. c Heatmaps of all DEGs in EAE further visualize the clustering of EAE. Values are Reads/Totals Reads normalized to the average of the CFA condition. DEG = differentially expressed gene