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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-α and stromal-derived cell factor 1

Fig. 5

Intrathecal injection of paclitaxel-activated astrocytes elicit allodynia via TNF-α and SDF-1. a Schematic illustration showing the experimental conditions of cultured astrocytes, intrathecal injection, and behavioral tests. b Effect of intrathecal (i.t.) injection of paclitaxel-activated astrocytes (astrocytes cultured with vehicle, paclitaxel for 1 or 6 h) on mechanical allodynia in male mice (*P < 0.05 compared to vehicle, ANOVA, n = 5 per group). c, d Effect of intrathecal (i.t.) administration of TNF-α or SDF-1 neutralizing antibody on mechanical allodynia induced by i.t. injection of paclitaxel-activated astrocytes in male mice (astrocytes cultured with paclitaxel for 1 h, *P < 0.05 compared to IgG control, ANOVA, n = 5 per group)

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Journal of Neuroinflammation

ISSN: 1742-2094