Blast traumatic brain injury and serum inflammatory cytokines: a repeated measures case-control study among U.S. military service members

Table 2 Comparisons of mean cytokine levels pre- and post-deployment/bTBI for controls, mild cases, and moderate/severe cases, via paired t-test

Gene/locus	Comparison	Control				Mild				Moderate+Severe
Gene/locus	Comparison	N	mean	s.e.	p-value	N	mean	s.e.	p-value	N	mean	s.e.	p-value
βNGF	Pre	47	89.72	22.39		89	70.45	18.64		50	63.54	10.69
βNGF	Post		50.57	9.35	0.10		66.00	15.98	0.84		56.14	14.28	0.70
IL-1ɑ	Pre	47	15.61	3.34		89	29.65	5.95		50	29.41	6.54
IL-1ɑ	Post		23.77	4.88	0.11		21.33	4.39	0.20		19.49	3.47	0.18
IL-1β	Pre	47	11.71	4.77		89	15.87	5.97		50	13.94	4.86
IL-1β	Post		13.27	4.74	0.81		6.05	1.61	0.12		5.96	1.97	0.15
IL-4	Pre	47	4.91	0.88		89	5.22	1.04		50	5.67	1.34
IL-4	Post		7.42	1.60	0.15		4.72	0.98	0.65		4.07	0.96	0.25
IL-6	Pre	47	39.69	14.86		89	34.76	9.19		50	52.10	16.69
IL-6	Post		44.82	9.75	0.77		24.94	3.95	0.32		20.50	5.44	0.08
IL-8	Pre	45	95.04	22.78		88	155.34	18.99		50	186.01	29.72
IL-8	Post		127.90	26.69	0.28		71.92	11.66	<0.01		78.34	17.08	<0.01
IL-10	Pre	47	10.62	1.77		89	10.17	1.86		50	9.64	1.28
IL-10	Post		9.38	1.85	0.58		10.08	1.81	0.95		10.00	1.94	0.87
IL-13	Pre	47	65.04	12.11		89	64.09	13.72		50	74.76	13.06
IL-13	Post		54.35	11.91	0.43		56.56	13.08	0.44		49.74	8.79	0.12
IL-17	Pre	47	63.89	10.84		89	66.67	10.85		50	78.87	11.47
IL-17	Post		78.76	19.05	0.45		81.13	16.26	0.27		63.12	11.78	0.29
MCP1	Pre	47	105.45	8.73		89	120.95	7.34		50	111.17	6.94
MCP1	Post		116.17	8.30	0.40		128.71	9.98	0.54		107.22	8.99	0.70
MMP3	Pre	47	20,732.20	1,297.38		85	21,995.44	966.14		49	21,679.60	1,144.74
MMP3	Post		22,591.80	1,428.18	0.33		20,043.55	971.06	0.10		18,310.36	1,235.37	0.07
TGFβ1	Pre	47	5,097.67	999.86		89	5,378.17	943.02		50	4,739.94	774.48
TGFβ1	Post		4,649.21	1,279.54	0.79		4,663.20	1,163.21	0.50		2,873.00	647.87	0.05
TNFɑ	Pre	47	682.54	96.21		89	644.05	85.58		50	702.38	107.64
TNFɑ	Post		690.78	127.97	0.96		706.96	89.89	0.59		528.07	84.81	0.20

ISSN: 1742-2094