Fig. 3

Elamipretide (SS-31) increased the consolidated long-term fear memory in LPS-treated mice. a Representative time distribution of freezing, immobility and mobility on day 2 of the fear conditioning (FCT) extinction test in indicated groups of mice. b In the contextual fear conditioning, the freezing response during habituation (hab) and acquisition were analyzed for 2 min per trial. A foot shock was given at the end of habituation and the first three conditioning trials. c The freezing time was measured in the chamber for 6 min without reinforcing the shock on day 2 of the FCT extinction test. Data are expressed as the mean ± SE (n = 6–8). ***P < 0.001 vs. CON group; ##P < 0.01 vs. LPS group; &P < 0.05, &&P < 0.01 vs. hab. FCT fear conditioning test, SS-31 elamipretide, aCSF artificial cerebrospinal fluid, LPS lipopolysaccharide, SE standard error