Fig. 7

Suppression of HDAC2 restored cognitive dysfunction induced by LPS. a, b The suppression of HDAC2 expression significantly improved the impairments in context-dependent fear memory and tone-dependent fear memory observed after LPS administration (n = 10). c The suppression of HDAC2 expression significantly improved the impaired object discrimination observed after LPS administration, as revealed by similar percentages for visiting familiar object 1 and novel object 3 (n = 10). d Compared with those in the LPS group, the mice in the LPS + ShHdac2 group showed a preference for novel object 3 (n = 10). Data are presented as the mean ± S.E. M. ^*P < 0.05; ^**P < 0.01; and ^***P < 0.001