Fig. 7

Schematic description of LPS-mediated suppression of autophagy, which leads to microglial activation. LPS activates MTOR via phosphorylation, leading to the decreased expression of Vps34 which causes a reduction of PI(3)P. The PI(3)P deficiency restricts maturation of omegasomes to phagophores and thus inhibits the formation of autophagosomes, which ultimately increases the activation of microglial cells