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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation

Fig. 7

Schematic description of LPS-mediated suppression of autophagy, which leads to microglial activation. LPS activates MTOR via phosphorylation, leading to the decreased expression of Vps34 which causes a reduction of PI(3)P. The PI(3)P deficiency restricts maturation of omegasomes to phagophores and thus inhibits the formation of autophagosomes, which ultimately increases the activation of microglial cells

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