Fig. 1

a Venn diagram illustrating the relations among the genes differentially expressed in the precentral gyrus in control healthy donor tissue compared with grey matter lesion (GML) and normal appearing grey matter (NAGM) of both F+ SPMS and of F− SPMS cases. Each oval represents the list of genes differentially expressed between one condition and control group (p < 0.05 fold change > 1.5). Numbers in each overlapped area indicate the numbers of differently expression genes shared by two or more conditions. Numbers in non-overlapping portion of each oval show the number of transcripts uniquely deregulated in one condition. The brown intersection in the middle represents genes which are significantly differentially expressed in all different conditions vs controls consistently. b Table reporting the list of the ten most regulated upregulated and downregulated genes in each examined condition: grey matter lesion and normal appearing grey matter in follicle-positive or follicle-negative MS cases respect to healthy controls. For each listed gene, the fold change of gene expression respect to controls and the p value of the univariate test is expressed