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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Recombinant CC16 inhibits NLRP3/caspase-1-induced pyroptosis through p38 MAPK and ERK signaling pathways in the brain of a neonatal rat model with sepsis

Fig. 3

Pathological changes of the cortex detected in each group at 12 h. a Sham group, the cerebral cortex of the rats was normal. b CLP group, neuron degeneration (red arrows), nerve cell atrophy (yellow arrows), inflammatory cell infiltration (black arrows). c CLP + rCC16 group, the cortex was relatively normal, with occasional atrophy of nerve cells (yellow arrow). d CLP + U46619 group, brain tissue edema, a large number of degenerate neurons (red arrows), nerve cell atrophy (yellow arrows), visible inflammatory cell infiltration (black arrow). e CLP + rCC16 + U46619 group, some degenerative neurons (red arrows) and a small amount of inflammatory cell infiltration (black arrow) are seen. Scale bar = 50 μm

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Journal of Neuroinflammation

ISSN: 1742-2094