Fig. 5

DRD3 deficiency results in unresponsiveness of astrocytes upon systemic LPS treatment. Wild-type (WT) or DRD3 knockout (DRD3KO) mice received an i.p. injection of LPS (5 mg/kg) or PBS. After 3 h, mice were sacrificed, and astrogliosis was analysed by immunohistochemical analysis of GFAP in the striatum. a Representative overview images at low magnification are shown (bar, 100 μm). b Quantification of GFAP immunoreactivity density. Data from five to six mice per group is shown. Values are the mean ± SEM. *p < 0.05 by two-way ANOVA followed by Sidak’s post-hoc test