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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

Fig. 6

Effects of URB, autophagy inhibitor 3-MA, lysosome inhibitor CQ and microglial activation inhibitor minocycline on CCH-induced impaired autophagy. a Representative western blot for LC3, p62, LAMP1, OX-42 and β-actin in the hippocampus. b Relative optical density analysis for LC3 in the hippocampus. c Relative optical density analysis for p62 in the hippocampus. d Relative optical density analysis for LAMP1 in the hippocampus. e Relative optical density analysis for OX-42 in the hippocampus. Data are expressed as mean ± SEM (n = 5). *P < 0.05 versus sham group. **P < 0.05 versus BCCAo group. #P < 0.05 versus BCCAo+URB group

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Journal of Neuroinflammation

ISSN: 1742-2094