Fig. 3
From: Complement factor H contributes to mortality in humans and mice with bacterial meningitis
Expression of FH during experimental pneuomococcal meningitis and the effect of FH deficiency on clinical severity and survival. FH brain levels are increased during experimental pneumococcal meningitis at 6, 24, and 48 h after infection compared to saline inoculated mice (a). Lines represent median values, P values were determined with the Mann-Whitney U test. Kaplan-Meier curve of wt and Cfh−/− mice with pneumococcal meningitis. P value was determined with the log-rank test (b). Clinical severity scores for Cfh−/− mice increased faster as compared to wt mice (0.112 vs. 0.088 points/h). P value was determined using exponential regression (c)