Fig. 5
From: Complement factor H contributes to mortality in humans and mice with bacterial meningitis
Adjuvant treatment with human FH in experimental pneumococcal meningitis. Mortality rates were similar between hFH- and PBS-treated mice (45% vs. 50%) (a). Bacterial outgrowth was increased in hFH-treated mice compared to PBS-treated mice in lung and spleen at 24 h after infection (b). Activation of the terminal complement pathway indicated by C5b-9 level was significant lower in mice treated with hFH compared to mice treated with PBS in the brain at 48 h after infection, median 9.37 μg/mg tissue vs. 11.71 μg/mg tissue (c). Lines represent median values and error bars are interquartile ranges, P values were determined with the Mann-Whitney U test