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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Microglial depletion and repopulation in brain slice culture normalizes sensitized proinflammatory signaling

Fig. 10

Microglial repopulation reduces proinflammatory responses to ethanol. OHSCs after microglial depletion and repopulation were treated with ethanol (100 mM) for 4 days and then followed by RT-PCR analysis. a Ethanol caused a 13-fold induction of IL-1β in naïve 28DIV slices. Microglia-repopulated slices showed reduced induction of IL-1β (6.4-fold vs control, 48% reduction). b Ethanol caused a 5-fold induction of TNFα in naïve 28DIV slices. Microglia-repopulated slices showed reduced induction of TNFα (2.2-fold vs control, 55% reduction). **p < 0.01, ***p < 0.001 vs control, †p < 0.05 vs ethanol. c Illustration depicting changes in immune gene expression in response to ethanol after microglial repopulation

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Journal of Neuroinflammation

ISSN: 1742-2094