Table 1 MPTP mouse model groups
Groups (n = 10–15/group) | Treatment (day1–5) |
|---|---|
Control | Vehicle |
MPTP | 20 mg/kg, once daily, i.p. day1–5 |
MPTP+senicapoc | MPTP (20 mg/kg, once daily, i.p. day1–5) + senicapoc (100 mg/kg, once daily, p.o. day1–5, 1 h prior to MPTP exposure) |
Senicapoc | 100 mg/kg, once daily, p.o. day1–5 |
WT | Vehicle |
KCa3.1−/− | Vehicle |
WT+MPTP | 20 mg/kg, once daily, i.p. day1–5 |
KCa3.1−/−+MPTP | 20 mg/kg, once daily, i.p. day1–5 |