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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex

Fig. 4

Intra-neuronal labeling of C1q within dendritic spines in aged monkey dlPFC layer III. a–d Postsynaptic C1q in dendritic spines in aged monkey dlPFC is prominently associated with the smooth endoplasmic reticulum (SER) spine apparatus (pink pseudocolored) and is observed in perisynaptic or extrasynaptic locations near the PSD. d C1q protein is also visualized within the glutamatergic-like PSD per se. Synapses are between arrows. Color-coded arrowheads (purple) point to C1q immunoreactivity. Profiles are pseudocolored for clarity. Ax, axon; Sp, spine; Mit, mitochondria. Scale bars, 200 nm

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Journal of Neuroinflammation

ISSN: 1742-2094