Table 3 Multimarker score and prediction of poor outcome

Cytokines included in the score*

 IL-12p70, Coef (95%CI)

− 0.60 (− 1.03 to − 0.17)

<0.01

 IL-10, Coef (95%CI)

0.61 (0.27–0.94)

<0.01

 TNFα, Coef (95%CI)

− 0.45 (− 0.82 to − 0.08)

0.02

 Plasma IL-6, Coef (95%CI)

0.46 (0.02–0.90)

0.04

Score, per 1- unit increment

 Unadjusted OR (95%CI)

3.24 (2.22–4.73)

<0.01

 Adjusted† OR (95%CI)

2.72 (1.86–3.99)

<0.01

c Statistics

 Best-fit clinical model, AUC (95%CI)

0.731 (0.668–0.794)

0.02

 Best-fit clinical model + multimarker score, AUC (95%CI)

0.808 (0.755–0.861)

IDI (95%CI)

0.125 (0.084–0.167)

<0.01

Continuous NRI (95%CI)

0.672 (0.437–0.907)

<0.01

Categorical NRI (95%CI)

0.249 (0.122–0.375)

<0.01