Fig. 10
From: Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice
Dectin-1, Syk and p-Syk expression was significantly increased in primary microglial cells with OGD/R exposure. LAM/PIC pretreatment significantly decreased p-Syk, TNF-α, and iNOS expression in primary microglial cells following OGD/R exposure. a, b Dectin-1, p-Syk, TNF-α, and iNOS expression levels were significantly enhanced in primary microglial cells with OGD/R exposure compared with primary microglial cells without OGD/R exposure. LAM pretreatment significantly decreased the expression levels of Dectin-1, p-Syk, TNF-α, and iNOS in primary microglial cells with OGD/R exposure (n = 3/group; *P < 0.05 vs. control group; #P < 0.05 vs. OGD/R group). c, d PIC pretreatment significantly inhibited p-Syk, TNF-α, and iNOS expression in primary microglial cells with OGD/R exposure compared with cells without OGD/R exposure (n = 3/group; *P < 0.05 vs. control group; #P < 0.05 vs. OGD/R group)