Fig. 11
From: Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice
Effects of knockdown Dectin-1 or Syk on inflammatory responses in OGD/R-induced BV2 cells. a, b The Dectin-1 siRNA decreased Dectin-1 expression in BV2 cells with OGD/R exposure (n = 3/group; &P < 0.05 vs. control siRNA group). The expression levels of p-Syk, TNF-α, and iNOS were also downregulated in OGD/R + Dectin-1 siRNA group compared with that of the BV2 cells in OGD/R + control siRNA group (n = 3/group; *P < 0.05 vs. control siRNA group; #P < 0.05 vs. OGD/R + control siRNA group). c, d The Syk siRNA decreased Syk expression in BV2 cells (n = 3/group; &P < 0.05 vs. control siRNA group). Knockdown Syk also attenuated the production of p-Syk, TNF-α, and iNOS in BV2 cells in the OGD/R + Syk siRNA group compared with the OGD/R + control siRNA group (n = 3/group; *P < 0.05 vs. control siRNA group; #P < 0.05 vs. OGD/R + control siRNA group)