Fig. 6

Microglial migration and activation for the phagocytosis of hTau40^WT oligomers. Extracellular Tau aggregates or oligomers have induced the activation state of microglia with high Iba1 and modified actin cytoskeleton network, which ultimately leads to the rapid phagocytosis and clearance of Tau oligomers. Extracellular leakage of Tau species from damaged neurons can act as a trigger for microglial activation and migration, which ultimately will be beneficial as a biomarker for early onset and as a target for therapy