Fig. 8

Inhibition of NMDAR or calpain attenuated hippocampal dendritic density loss after anesthesia and surgery. a A hippocampal profile image of Golgi-Cox staining. b Representative camera tracings of hippocampal CA1 neurons of the six groups. c Quantitation of the dendritic intersections of the six groups. d Quantitation of the total dendritic length of the six groups. e Representative dendritic spine density of hippocampal CA1 neurons of the six groups. f Quantitation of the dendritic spine density of the six groups. Data are presented as the mean ± SEM (n = 6). *p < 0.05 compared to the con + veh group (**p < 0.01, ***p < 0.001), ^#p < 0.05 compared to the sur + veh group (^##p < 0.01, ^###p < 0.001)