Fig. 1

The effect of isotalatizidine on acetic acid-induced somatic pain in mice. (a) The chemical structure of isotalatizidine. Isotalatizidine significantly decreased the writhing times (b) and increased the rate of analgesia (c) in acetic acid-induced mice. The ED₅₀ of analgesic efficiency of isotalatizidine was 0.43 mg/kg (d). Data are expressed as mean ± SEM (n = 8 mice in each group). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 vs. vehicle group