Fig. 2

Isotalatizidine treatment improved sciatic nerve ligation-induced chronic neuropathic pain. Neuropathic pain mice were induced by tight ligation of sciatic nerve, the withdrawal thresholds within 12 days after surgery (a) and intrathecal injection of vehicle (0.9% normal saline) or isotalatizidine (0.1, 0.3, 1.0 mg/kg) 8 days after surgery (b) were measured by Von Frey Monofilament in both contralateral and ipsilateral paws. Data are expressed as means ± SEM (n = 6 mice in each group). ^*P < 0.05, ^**P < 0.01 vs. saline group, ^***P < 0.001 vs. sham group