Fig. 3
From: Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer’s disease mice
Zymosan neurotoxicity is selective for neurons. a Quantification of total cortical cell number was performed by counting Dapi+ nuclei. Total cell numbers were not affected by ICV injection of zymosan. b Staining for GFAP+ astrocytes showed ICV injection of zymosan had a minimal effect in wt mice at 3 days, 2 weeks, and 28 days as compared with PBS-injected mice. In the 5xFAD brains, there was strong GFAP immune-reactivity in PBS-injected mice, which did not further increase in response to zymosan ICV. c Quantification of GFAP-immune-reactivity (as % of image area) showed the massive astrogliosis in 5xFAD mice at all time points, unaffected by zymosan