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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Suppression of histone deacetylases by SAHA relieves bone cancer pain in rats via inhibiting activation of glial cells in spinal dorsal horn and dorsal root ganglia

Fig. 1

TCI-induced bone destruction and mechanical allodynia. a Radiographs of the tibia bone in the Sham and TCI rats on POD 21. b HE staining of the trabecular bone in the Sham and the TCI group on POD 21. b (i, ii) Representative images of HE staining showed regular arrangement of trabecular bone (asterisks) in tibial marrow cavity of the Sham group. b (iii, iv) Representative images of HE staining showed cancer cells (within the dotted lines) and osteoclastic resorption pits (arrows) on trabecular surface in tibial marrow cavity of the TCI group on POD 21. Original magnification: 100 (top row), 200 (bottom row). c TCI-induced prominent mechanical allodynia from POD 5 to POD 28 (n = 8). Data are expressed as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 versus the Sham group

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Journal of Neuroinflammation

ISSN: 1742-2094