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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy

Fig. 1

Quantitative analysis of progressive accumulation of microvascular CAA in rTg-DI rats. a–f Brain sections from 3-month-old (a–c) and 12-month-old (d–f) rTg-DI rats were immunolabeled with rabbit polyclonal antibody to collagen IV to specifically detect cerebral microvessels (red) and the thioflavin S to identify fibrillar amyloid (green). The rTg-DI rats showed progressive cerebral microvascular fibrillar amyloid deposition in the cortical (a, d), hippocampal (b, e), and thalamic regions (c, f). Scale bars = 50 μm. g Quantitation of cerebral microvascular amyloid load in different brain regions of 3-month-old (black bars) and 12-month-old (gray bars) rTg-DI rats. Data are expressed as means ± SD of n = 6–7 rTg-DI rats per group. ***P < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094