Fig. 2

Sema4A KO EAE receiving Th17-skewed encephalitogenic T cells are resistant to IFN-β mediated exacerbation. IFN-β treatment exacerbated clinical score of Th17-induced WT recipient mice; however, no significant change was observed among the Sema4A KO recipient mice (a). Infiltration of mononuclear cells was not augmented in the spinal cord of Sema4A KO recipient mice receiving IFN-β treatment (b). Data are expressed as means ± SEM. *P < 0.05 for WT vs. WT+IFN; ^#P < 0.05 for WT vs. 4AKO+IFN. Scale bars, 20 μm