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Table 1 Predicted KEGG functional pathway differences at level 2 inferred from 16S rRNA gene sequences using PICRUSt

From: Supplement of microbiota-accessible carbohydrates prevents neuroinflammation and cognitive decline by improving the gut microbiota-brain axis in diet-induced obese mice

KO functional categories Con mean% (SEM%) HF-FD mean% (SEM%) HF-MAC mean% (SEM%) Con vs HF-FD p value HF-MAC vs HF-FD p value
Level 1 Level 2
Metabolism Glycan biosynthesis and metabolism 3.404 (0.080) 2.676 (0.086) 2.971 (0.071) 0.008
Environmental information processing Signal transduction 2.122 (0.032) 2.712 (0.059) 2.155 (0.035) 0.008 0.003
Environmental information processing Signaling molecules and interaction 0.208 (0.003) 0.201 (0.005) 0.194 (0.003) 0.009
Cellular processes Cell motility 3.481 (0.122) 5.016 (0.244) 3.995 (0.149) 0.008 0.018
Cellular processes Transport and catabolism 0.584 (0.017) 0.402 (0.019) 0.473 (0.012) 0.008
Human diseases Neurodegenerative diseases 0.173 (0.003) 0.177 (0.004) 0.168 (0.002) 0.015
Human diseases Metabolic diseases 0.121 (0.003) 0.095 (0.004) 0.113 (0.003) 0.013 0.009
Organismal systems Environmental adaptation 0.186 (0.004) 0.221 (0.000) 0.199 (0.003) 0.016 0.018
Organismal systems Digestive system 0.028 (0.001) 0.019 (0.003) 0.029 (0.002) 0.040
  1. Data is expressed as mean (%) (SEM%). KEGG Kyoto Encyclopedia of Genes and Genomes, PICRUSt Phylogenetic Investigation of Communities by Reconstruction of Unobserved States, KO KEGG ortholog; SEM standard error