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Table 1 Predicted KEGG functional pathway differences at level 2 inferred from 16S rRNA gene sequences using PICRUSt

From: Supplement of microbiota-accessible carbohydrates prevents neuroinflammation and cognitive decline by improving the gut microbiota-brain axis in diet-induced obese mice

KO functional categoriesCon mean% (SEM%)HF-FD mean% (SEM%)HF-MAC mean% (SEM%)Con vs HF-FD p valueHF-MAC vs HF-FD p value
Level 1Level 2
MetabolismGlycan biosynthesis and metabolism3.404 (0.080)2.676 (0.086)2.971 (0.071)0.008
Environmental information processingSignal transduction2.122 (0.032)2.712 (0.059)2.155 (0.035)0.0080.003
Environmental information processingSignaling molecules and interaction0.208 (0.003)0.201 (0.005)0.194 (0.003)0.009
Cellular processesCell motility3.481 (0.122)5.016 (0.244)3.995 (0.149)0.0080.018
Cellular processesTransport and catabolism0.584 (0.017)0.402 (0.019)0.473 (0.012)0.008
Human diseasesNeurodegenerative diseases0.173 (0.003)0.177 (0.004)0.168 (0.002)0.015
Human diseasesMetabolic diseases0.121 (0.003)0.095 (0.004)0.113 (0.003)0.0130.009
Organismal systemsEnvironmental adaptation0.186 (0.004)0.221 (0.000)0.199 (0.003)0.0160.018
Organismal systemsDigestive system0.028 (0.001)0.019 (0.003)0.029 (0.002)0.040
  1. Data is expressed as mean (%) (SEM%). KEGG Kyoto Encyclopedia of Genes and Genomes, PICRUSt Phylogenetic Investigation of Communities by Reconstruction of Unobserved States, KO KEGG ortholog; SEM standard error