Fig. 7

miR-873a-5p treatment inhibits the inflammatory response by promoting microglia polarization to M2 after TBI. a–c miR-873a-5p treatment significantly reduced the mRNA expression of CD32, INOS and IL-1β in the cortex at 1, 3 and 7 days after TBI. d–f miR-873a-5p increased the expression of the M2 microglia signature genes CD206, IL4 and Arg1 in the cortex at 1, 3 and 7 days after TBI. g, h Representative images of double immunofluorescent staining in the injured cortex with the microglial marker Iba1 (green) and the M1 marker iNOS (red). i, j Representative images of double immunofluorescent staining in the injured cortex with the microglia marker Iba1 (green) and the M2 marker Arg1 (red). Bar = 50 μm (data were presented as mean ± SD, compared with the sham group *p < 0.05, **p < 0.01, ***p < 0.001; compared with the TBI group ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, n = 5, one-way ANOVA)