Fig. 3

APP/PS1 overexpression increases GFAP coverage and complexity in the EC of 10-month-old mice. Representative images of the EC of 10-month-old WT-CTL (a), WT-ES (b), APP/PS1-CTL (c), and APP/PS1-ES (d) mice. GFAP coverage in the EC was increased in APP/PS1 mice (e). APP/PS1 increased GFAP+ cell complexity in the EC as shown by increased number of intersections (f), area under the curve (AUC) (g), and number of primary processes (h). Dots in Sholl analysis graphs are color-coded per animal. Statistical analyses were performed using two-way ANOVA. ^$Significant effect of genotype p < 0.05, scale bars 250 μm