Fig. 5

Relationship between astrocytes, microglia, and plaque load in APP/PS1 mice. a Summary of microglia and plaque load as published in [14]. b Global GFAP is increased in the dentate gyrus (DG) of 4-month-old (4 months) ES-exposed APP/PS1 mice after normalizing to number of amyloid-β + cells. c Masked GFAP is decreased in the DG of 10-month-old (10 months) ES-exposed APP/PS1 mice after normalizing to extracellular plaque load. d, e Pearson correlation coefficients visualized from − 1 (blue) to + 1 (red), with the size of the circles representing the correlation coefficients. Circles without crosses are correlation coefficients significant at p < 0.05. d Correlation matrix of staining data from 4-month APP/PS1 mice. e Correlation matrix between staining data from 10-month APP/PS1 mice. f CD68 coverage is negatively correlated with the number of amyloid-beta positive cells in the DG at 4 months. g CD68 coverage is positively correlated to masked GFAP coverage in the CA region of 10 months APP/PS1 mice. ^*Significant effect of condition p < 0.05