Fig. 6From: Vitamin B12 is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylationEffects of BM and adjuvant therapy with vitamin B12 on Dnmt3a and Tet1 expression in the hippocampus. Dnmt3a and Tet1 mRNA levels in the hippocampus were assessed by the 2−ΔΔCt method. Ppia was used as a reference gene. The effects of the BM and vitamin B12 were compared using a 2-way ANOVA (Bonferroni post hoc test). P values in tables below the graphs refer to the 2-way ANOVA and asterisks refer to the post hoc test. *P < 0.05; **P < 0.01; ***P < 0.001Back to article page