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Table 2 Individual clinical, autopsy, and neuropathology details in white matter and gray matter of secondary progressive MS patients

From: Interleukin-9 regulates macrophage activation in the progressive multiple sclerosis brain

CaseMS 92MS 121MS 160MS 180MS 234MS 286MS 342MS 356MS 389MS 473
Sex/age at death (years)F/38F/49F/44F/44F/39M/45F/35F/45F/55F/39
Onset (years)21352826242930292827
Disease duration (years)1714161815165162712
Meningeal inflammation++++
Perivascular infiltration++++++
IL-9+ in White matterNAWM++
Pre-active++++
Active++++++++
Chronic active+++
Remyelination++
Inactive+
IL-9+ in Gray matterNAGM
Pre-active
Active+++
Chronic active++++
Remyelination
Inactive+
  1. The degree of meningeal and perivascular inflammation was scored as −, absent; +, present; and ++, abundant. Similarly, the presence of IL-9 expressing (IL-9+) cells in the different types of lesions was scored as: −, absent; +, present; and ++, abundant. Tissues are classified as follows: normal appearing white matter (NAWM), normal appearing gray matter (NAGM), pre-active, chronic active, remyelination, and inactive