Table 2 Individual clinical, autopsy, and neuropathology details in white matter and gray matter of secondary progressive MS patients
From: Interleukin-9 regulates macrophage activation in the progressive multiple sclerosis brain
Case | MS 92 | MS 121 | MS 160 | MS 180 | MS 234 | MS 286 | MS 342 | MS 356 | MS 389 | MS 473 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
Sex/age at death (years) | F/38 | F/49 | F/44 | F/44 | F/39 | M/45 | F/35 | F/45 | F/55 | F/39 | |
Onset (years) | 21 | 35 | 28 | 26 | 24 | 29 | 30 | 29 | 28 | 27 | |
Disease duration (years) | 17 | 14 | 16 | 18 | 15 | 16 | 5 | 16 | 27 | 12 | |
Meningeal inflammation | + | – | + | + | – | + | – | – | – | – | |
Perivascular infiltration | + | + | – | – | + | + | + | – | + | – | |
IL-9+ in White matter | NAWM | – | + | – | – | – | + | – | – | – | – |
Pre-active | – | – | – | – | ++ | ++ | – | – | – | – | |
Active | – | – | – | – | – | – | ++ | ++ | ++ | ++ | |
Chronic active | + | + | – | – | – | + | – | – | – | – | |
Remyelination | – | – | + | – | + | – | – | – | – | – | |
Inactive | – | – | – | – | – | + | – | – | – | – | |
IL-9+ in Gray matter | NAGM | – | – | – | – | – | – | – | – | – | – |
Pre-active | – | – | – | – | – | – | – | – | – | – | |
Active | – | – | + | – | + | + | – | – | – | – | |
Chronic active | – | + | + | – | + | + | – | – | – | – | |
Remyelination | – | – | – | – | – | – | – | – | – | – | |
Inactive | – | – | – | – | + | – | – | – | – | – | |