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Table 2 Individual clinical, autopsy, and neuropathology details in white matter and gray matter of secondary progressive MS patients

From: Interleukin-9 regulates macrophage activation in the progressive multiple sclerosis brain

Case MS 92 MS 121 MS 160 MS 180 MS 234 MS 286 MS 342 MS 356 MS 389 MS 473
Sex/age at death (years) F/38 F/49 F/44 F/44 F/39 M/45 F/35 F/45 F/55 F/39
Onset (years) 21 35 28 26 24 29 30 29 28 27
Disease duration (years) 17 14 16 18 15 16 5 16 27 12
Meningeal inflammation + + + +
Perivascular infiltration + + + + + +
IL-9+ in White matter NAWM + +
Pre-active ++ ++
Active ++ ++ ++ ++
Chronic active + + +
Remyelination + +
Inactive +
IL-9+ in Gray matter NAGM
Pre-active
Active + + +
Chronic active + + + +
Remyelination
Inactive +
  1. The degree of meningeal and perivascular inflammation was scored as −, absent; +, present; and ++, abundant. Similarly, the presence of IL-9 expressing (IL-9+) cells in the different types of lesions was scored as: −, absent; +, present; and ++, abundant. Tissues are classified as follows: normal appearing white matter (NAWM), normal appearing gray matter (NAGM), pre-active, chronic active, remyelination, and inactive